In the first part I presented a workflow to export a SimBiology
model as well as data to the workspace from the SimBiology Desktop,
speed up its simulation and prepare it for parallel computation. Here I
will set up the actual optimization problem.
The Optimization solvers usually only accept a …
Under some circumstances the parameter estimation tasks built into
SimBiology® (sbioparamestim and sbionlinfit) and the SimBiology
Desktop (sbionlinfit) are not robust enough for the given data, the
model or the initial parameter values.
If the objective function has many local minima - which is nearly always the case for complex systems …