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The aim of this tutorial is to provide people working in the biosciences with little to no background in programming an accessible and short tutorial on MATLAB basics for common bioscience workflows. It was developed for some courses here at the EMBL and includes exercises …

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Exercise 1

% there are several ways for creating these arrays
% 1 - squared brackets
A = [1 3 5; 3 6 3; 9 8 5]
% 2 - functions for array creation
A = rand(3)
A = magic(3) 

b = [3; 4: 8] % 3 x 1 - column vector!

A * b(1)
A …

Previous articles explored julia and its plotting facilities in the Winston package. The workflow used there, (i) data import, (ii) plotting and (iii) graphics export, will be used in this article as well, however, this time using Dataframes and Gadfly in julia and dataset arrays in MATLAB.

Dataset arrays are …

In the last posts I installed julia, some graphics packages and some dependencies on a Mac and compared one way of plotting in julia - using Winston and plotting several datasets into one plot - with the typical approach in MATLAB. This post will show how to plot each individual dataset into …

A number of excellent free open-source alternatives to MATLAB have arrived in the last couple of years that have managed to bite away parts of MATLAB's market share. Most notable are R, which is now the dominant language for statistical computing and bioinformatics and Python (with numpy, scipy etc.) which …

The SimBiology Desktop offers a number of different plot types that can be chosen in a task window. The default plot type in a simulation task, for example, is the Time plot, which plots states against the simulation time:

Three items need to be configured for this plot type:

• tobj …

In the first part I presented a workflow to export a SimBiology model as well as data to the workspace from the SimBiology Desktop, speed up its simulation and prepare it for parallel computation. Here I will set up the actual optimization problem.
The Optimization solvers usually only accept a …

Under some circumstances the parameter estimation tasks built into SimBiology® (sbioparamestim and sbionlinfit) and the SimBiology Desktop (sbionlinfit) are not robust enough for the given data, the model or the initial parameter values.

If the objective function has many local minima - which is nearly always the case for complex systems …